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Treating chronic pain and other medical conditions with THC and CBD oil In addition, CBD can interact with warfarin and increase the risk of bleeding 28 Jun 2019 CBD use is on the rise, however, it may interact with over-the-counter this may be a good time to ask if oral CBD oil may also interact with your medication. Drugs used to thin blood, such as warfarin (Coumadin), and drugs Does hemp CBD oil interfere with Coumadin? – HelloMD I have breast cancer and a clotting problem. I'm on Coumadin. Answers Answer - Dr. Cheryl Bugailiskis All derivatives of cannabis can affect other drugs as they are processed through the liver. Cannabis tends to increase your INR while on Coumadin. This affect tends to … Does Cbd Oil Interact With Coumadin While some hereditary Does Cbd Oil Interact With Coumadin links seem to exist, other causes – though hotly debated – have been difficult to nail down with any clarity. The symptoms range Does Cbd Oil Interact With Coumadin in both type and severity, from one individual to another.